(4/8) Dr. Matt Lockett

Dr. Matt Lockett

University of North Carolina
Department of Chemistry

Friday, April 8, 2022
12:00 Noon
Host: Dr. Chengpeng Chen

“New tools to evaluate cellular responses to physiological oxygen tensions”

This talk will explore the analytical challenges that arise when converting cell-based assays from their traditional monolayer format to (3D) tissue-like structures. Using paper-based cultures as a model system, we will cover our current efforts to 1) evaluate oxygen’s role in drug resistance in model colorectal tumors, 2) quantify xenobiotic metabolism in liver models, 3) probe hormone regulation in breast tissue and tumor models, and 4) screen large libraries of per- and poly-fluorinated substances.