UC Davis Health Department of Biochemistry and Molecular Medicine
Friday, May 5, 2023
12:00 Noon
Room 120 – Meyerhoff Chemistry Building
Host: Dr. Kamal Seneviratne
“Recombinant RNAs for Research and Therapy”
In this talk, Dr. Yu will provide a brief introduction of the role of noncoding RNAs in posttranscriptional gene regulation and RNAs as a new class of molecules for therapy and their unique mechanisms of actions, as compared with small-molecule and protein therapeutics. I will discuss why and how we develop the tRNA/pre-miRNA-based recombinant RNA technology that offers a consistent, high-yield, and large-scale in vivo fermentation production of true biologic RNA agents (BioRNAs) carrying payload small RNA molecules, such as miRNAs, siRNAs, and aptamers. Examples will be provided to illustrate the utilities of unparalleled BioRNAs for the investigation of xenobiotic and endobiotic metabolism and disposition, as well as the evaluation of therapeutic RNAs.