(2/4/2022) Dr. Dana Ferraris

Dr. Dana Ferraris

McDaniel College – Department of Chemistry

Friday, February 4, 2022
12:00 Noon – Webex
Host: Dr. Paul Smith

“The design, synthesis and evaluation of mono (ADP-ribosyl) transferase inhibitors as chemical probes for validation of drug discovery targets”

Undergraduate medicinal chemistry research can be very challenging in an academic environment. Several factors hinder the ability of faculty to offer such research experiences. For example, budgetary constraints, time constraints, lack of students in their particular discipline, and the willingness/ interest levels of students are just few barriers to be navigated. The McDaniel Medicinal Chemistry labs have synthesized several mono(ADP-ribosyl)transferase inhibitors to serve as probes for unvalidated drug targets such as PARP10 and PARP14. They were tested through collaboration to help identify the mechanism by which cells respond to coronavirus infection. This research was conducted prior to the COVID-19 outbreak and helped to validate the coronavirus nsp3 macrodomain as a valid drug discovery target.