Department of Chemistry and Biochemistry, University of Maryland, College Park, MD
Friday, October 25, 2019
Meyerhoff room 120, 12 Noon
In this talk I will present our recent work on the preparation and use of macrocyclic and acyclic CB[n] (1 and 2) in biologically relevant applications. For example, I will discuss the use of acyclic CB[n] as a solubilizing excipient for insoluble drugs, as a reversal agent for neuromuscular block as well as hyperlocomotion induced by drugs of abuse (e.g. methamphetamine), the preparation of metal organic polyhedra that are either covalently or non-covalently functionalized with CB[n], and new acyclic CB[n] featuring triptycene sidewalls.
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