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Dr. Lyle Issacs

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD

Friday, October 25, 2019

 Meyerhoff room 120, 12 Noon

In this talk I will present our recent work on the preparation and use of macrocyclic and acyclic CB[n] (1 and 2) in biologically relevant applications.  For example, I will discuss the use of acyclic CB[n] as a solubilizing excipient for insoluble drugs,[1] as a reversal agent for neuromuscular block as well as hyperlocomotion induced by drugs of abuse (e.g. methamphetamine),[2] the preparation of metal organic polyhedra that are either covalently or non-covalently functionalized with CB[n],[3] and new acyclic CB[n] featuring triptycene sidewalls.[4]

[1] G. Hettiarachchi, S. K. Samanta, S. Falcinelli, B. Zhang, L. Isaacs, V. Briken, Mol. Pharmaceut. 2016, 13, 809-818.

[2] S. Ganapati, P. Y. Zavalij, M. Eikermann, L. Isaacs, Org. Biomol. Chem. 2016, 14, 1277-1287.  S. Ganapati, S. D. Grabitz, S. Murkli, F. Scheffenbichler, M. I. Rudolph, P. Y. Zavalij, M. Eikermann, L. Isaacs, ChemBioChem 2017, 18, 1583-1588

[3] S. K. Samanta, D. Moncelet, V. Briken, L. Isaacs, J. Am. Chem. Soc. 2016, 138, 14488-14496.  S. K. Samanta, J. Quigley, B. Vinciguerra, V. Briken, L. Isaacs, J. Am. Chem. Soc. 2017, 139, 9066-9074.

[4] X. Lu, S. K. Samanta, P. Y. Zavalij, L. Isaacs, Angew. Chem. Int. Ed. 2018, 57, 8073-8078.  W. Liu, X. Lu, W. Xue, S. K. Samanta, P. Y. Zavalij, Z. Meng, L. Isaacs, Chem. Eur. J. 2018, 24, 14101-14110.  W. Liu, X. Lu, Z. Meng, L. Isaacs, L. Org. Biomol. Chem. 2018, 16, 6499-6506.