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Dr. Zachary Schultz

 

Dr. Zachary Schultz

The Ohio State University

Rescheduled to FALL 2020 – TBA

Host: Dr. Chris Geddes

“Enhanced Raman Scattering for Bioanalysis”

The identification and quantification of molecules in biological samples is key for understanding mechanisms associated with health and disease.  While a number of techniques are routinely used, these techniques focus attention on certain molecules that are readily characterized, leaving many molecules unexplored.  New techniques that provide complementary analysis may lead to the diagnostic and prognostic tools for tomorrow.  The enhancement of Raman signals by nanostructures, surface enhanced Raman scattering (SERS), provides a sensitive label-free method of chemical analysis. The combination of SERS with fluid dynamics, an approach we call sheath-flow SERS, enables ultrasensitive and high-throughput Raman characterization. Using sheath-flow SERS as a detector for chemical separations enables high throughput Raman characterization in biological fluids at relevant concentrations. Our results illustrate the utility of this approach for the detection and quantification of metabolites in biological samples, such as tumor lysates. In other work we utilize Raman enhancements from individual nanostructures to target and image protein receptors in living cells. These experiments obtain chemical, structural, and spatial information simultaneously. In protein-ligand binding experiments, our results show signals characteristic of the receptor’s binding site, which enable investigations of ligand recognition by membrane receptors in cells that are important for drug targeting. Overall, our work provides insight into the origin and utility of enhanced Raman signals for ultrasensitive bioanalysis