(10/29) Dr. Mei He

Dr. Mei He

University of Florida
Department of Pharmaceutics

Friday, October 29, 2021
12:00 Noon
Host: Dr. Chengpeng Chen

“3D tissue microenvironment and extracellular vesicles”

Extracellular vesicles, particularly exosomes, are emerging cellular massagers for understanding essential disease pathogenesis. We have found their secretion dynamics are very sensitive to tissue microenvironment. However, replicating 3D in vivo tissue microenvironment compartmentalized with distinct cellular micro-domains is extremely challenging, due to the complex changes of cell types and extracellular matrix. Our research group discovered 3D bioprinting and microfluidic technology for engineering 3D tissue system with micro-scale precision, which is able to mimic in-vivo like tissue function for secretion of extracellular vesicles and exosomes. Such cellular engineered exosomes carry tailored antigenic markers or combination of stimulating factors for developing precisely controlled therapeutic delivery agents and advancing cancer immunotherapy.