(12/04) Dr. Kathie Seley-Radtke
Dr. Kathie Seley-Radtke
UNIVERSITY OF MARYLAND BALTIMORE COUNTY
Department of Chemistry/Biochemistry
December 4, 2020
“Flex-nucleosides – a strategic approach to broad-spectrum antiviral therapeutics”
“Over the past several decades nucleos(t)ides have maintained a prominent role as one of the cornerstones of antiviral and anticancer therapeutics and many approaches to nucleos(t)ide and nucleic acid drug design have been pursued. One such approach involves flexibility in the sugar moieties of nucleos(t)ides, for example, in the highly successful anti-HIV and HBV drug Tenofovir. In contrast, introduction of flexibility to the nucleobase scaffold has only more recently gained significance with the invention of our fleximers. This flexibility has led to a significant improvement in antiviral activity, in some cases endowing the nucleoside potent activity when the parent rigid nucleoside was inactive, as well as the ability to overcome resistance mechanisms by engaging secondary amino acid residues not previously involved in the mechanism of action. The history of their development, as well as some of our most recent findings for this innovative class of nucleos(t)ides will be described.