CHEM 406/606 Bioinorganic Chemistry, Dr. Aaron T. Smith
Areas: Inorganic Chemistry, Biochemistry. This class is designed to give the participant an overview of how metals function in biological systems. The course comprises lectures, presentations, and primary literature as a means to survey cutting-edge advances in the field of bioinorganic chemistry. This class has three units: coordination chemistry of metals within biological systems; physical and spectroscopic characterization of metal interactions within biological systems; and mechanistic studies of metalloenzymes. NOTE that neither 405 nor 405L is required as a as a pre-requisite for this course.
CHEM 455/655 Biomedicinal Chemistry, Dr. Katherine Seley-Radtke
Areas: Organic Chemistry, Biochemistry. This survey course provides an introduction to drug design, discovery and development processes from a biological, organic chemistry and mechanistic standpoint. Basic principles of drug design and development, including modern rational approaches, various drug targets, the design and mechanistic features of various classes of inhibitors and prodrugs, DNA interactive drugs, toxicity, development of resistance, and patent issues will be covered.
CHEM 458 The Chemistry and Biochemistry of Brewing II, Steve Frazier and Dr. Paul Smith
Areas: Organic Chemistry, Biochemistry. This interdisciplinary course provides an in-depth exploration of the chemical and biochemical processes fundamental to the different stages of the brewing process. Topics will include an overview of wort production, yeast physiology and biochemistry, fermentation, beer finishing, beer aging, and sensory evaluation of the finished product. Integral to the course is the exploration of how fundamental chemical and biochemical processes affect different aspects of the brewing process as well as specific qualities of the beer produced.
CHEM 490/654 Advanced Synthetic Methods, Dr. Marcin Ptaszek
Area: Organic Chemistry. The course surveys modern methods of organic synthesis, including classical approaches (enolate chemistry, pericyclic reactions) and new methods (metal-catalyzed cross-coupling reactions, olefin metathesis). Scope and limitations for each method is discussed. Each method is illustrated by exemplary applications in total synthesis, medicinal chemistry, and materials chemistry, from the current chemical literature.
CHEM 490/684 Photochemistry and Photobiology: Concepts and Experimental Methods, Dr. Lisa Kelly
Areas: Physical Chemistry, Biochemistry. This course will focus upon the fundamental aspects of photophysical and photochemical phenomena. Fundamental aspects of the creation and fate of electronically excited states will be covered. The application of modern instrumentation to probe excited-state dynamics will be emphasized. Topics will include the theory and practical aspects of fluorescence and transient absorption spectroscopies. Representative topics include the interaction of light with molecular systems to (i) initiate and understand important light-initiated reactions, including photosynthesis, vision, and nucleic acid photochemistry and (ii) develop practical sensors for use in biological or environmental applications. Readings from the current literature will be used throughout the course to illustrate modern applications of photochemistry and photobiology.
CHEM 490/684 Advanced NMR Spectroscopy, Dr. Michael Summers
Areas: Biochemistry, Analytical Chemistry. This course focuses on theoretical aspects of solution-state NMR spectroscopy and their applications to chemical and biological systems. NMR theory is described using principles of classical and quantum mechanical physics. Emphasis is placed on theories behind methods commonly used for biomolecular structure/function studies, including the nuclear Overhauser effect, sensitivity enhancement of insensitive nuclei, and multi-dimensional NMR methods.
All elective courses listed above are approved for both CHEM and BIOC Majors.