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Katherine Seley-Radtke

Contact Information
Office: CHEM 405C
Phone: 410-455-8684

Professor

Post-Doctoral Auburn University 1996; Ph.D. Auburn University 1996; B.A. University of South Florida 1992

Professional Interests

Current Fields of Interest:

Medicinal/Synthetic Bioorganic/Organic Chemistry and Drug Design: Discovery, design and synthesis of nucleoside/nucleotide and heterocyclic enzyme inhibitors with chemotherapeutic emphasis in the areas of antiviral, anticancer, antibiotic, and antiparasitic targets. Primary goals include development of potent inhibitors to shut down disease replication pathways through a combination of cross-disciplinary synthetic, biological screening, mechanistic, and structure-based drug design techniques.

The primary focus for the Seley-Radtke laboratories involves the design and synthesis of flexible nucleoside (“fleximers”) and nucleobases (“flex-bases) inhibitors as a powerful approach to overcome the development of resistance to currently used therapeutics. The fleximers and flex-bases are able retain full potency when faced with “escape mutations” in biologically critical enzymatic systems – the inherent flexibility of the inhibitors allows them to conformationally adjust to steric and electronic clashes encountered in the binding site, and to engage secondary amino acids not previously involved in the enzyme’s mechanism of action. Potent activity has been uncovered with a series of “doubly flexible” acyclic nucleosides and their corresponding prodrugs against various viruses including coronaviruses such as SARS and MERS-CoV. This is particularly notable since to date, no cure has been approved and prior to our discovery, no nucleoside had successfully inhibited coronaviruses. Other targets under investigation with these structurally unique analogues include Ebola and Marburg by inhibition of viral polymerases with fleximers and their corresponding prodrugs. The prodrugs allow the nucleosides to bypass the first rate-limiting kinase-mediated phosphorylation in the requisite intercellular conversion to their biologically active triphosphate form. Other viral targets currently under investigation for the fleximers include Zika, Dengue and Yellow Fever, among other high priority neglected diseases.

Related to the above projects, the use of flex-nucleobases to inhibit the protein-protein interactions (PPIs) for the HIV nucleocapsid NCp7 is also being pursued. NCp7 is of high interest due to its multifunctional role in HIV replication. We have published extensively on a series of non-nucleoside HIV inhibitors (NNRTIs) containing nucleobases that have also shown dual activity against tuberculosis and influenza.

In addition to viral targets, another project focuses on the use of nucleobases as anticancer agents. For example, the potent activity exhibited by gemcitabine, Ara-C and other related FDA-approved anticancer analogues, has led to numerous structural modifications designed to increase target specificity and potency. Following upon the recent observation that several nucleobase analogues including thiophene-expanded purines, as well as pyrrolo – and thienopyrimidines designed in our laboratories have exhibited selective and highly potent (sub-nanomolar) levels of activity against several key cancers including lung, colon, leukemia, renal, and triple negative breast cancers (among others), we have initiated a program to elucidate their mechanism of action, as well as to further study their highly promising activity in vitro and in vivo. These compounds have advanced to animal studies and as well as investigations to elucidate their mechanism of action.

All of the projects being pursued in the Seley-Radtke laboratories employ structure activity relationship (SAR) algorithms for the biological enhancement of lead compounds. Intimately related to the goals of the drug design projects, synthetic organic research focus includes the discovery of unique strategies to solve design challenges using state of the art techniques for the construction of modified heterocycles, carbohydrates and carbocyclic moieties. In addition, a cross-disciplinary chemical biology approach employs enzymatic assays to survey the effectiveness of the potential drug candidates, as well as to investigate polymerase fidelity with modified nucleotide analogues that possess unique structural advantages for enhanced molecular recognition.

Publications

Selected Publications (Last 3 Years)

1. Yates, M. K.; Chatterjee, P.; Flint, M.; Arefeayne, Y.; Plavec, J.; Spiropoulou, C. F.; *Seley-
Radtke, K. L.; “Probing the Effects of Pyrimidine Functional Group Switches on Acyclic
Fleximer Analogues for Antiviral Activity” Molecules: Discovery, Design, Synthesis, and
Application of Nucleoside/Nucleotides” 2019, 24, 3184-3197,
doi.org/10.3390/molecules24173184.
2. Khandazhinskaya, A. L.; Matyugina, E. S.; Solyev, P. N.; Wilkinson, M.; Buckheit, K. W.;
Buckheit Jr., R. W.; Chernousova, L. N.; Smirnova, T. G.; Andreevskaya, S. N.; Kochetkov,
S. N.; De Koning, H. P.; *Seley-Radtke, K. L. “Biological Investigations for a Series of
Carbocyclic Nucleoside Analogues as Antibacterial Agents”, Molecules: Discovery, Design,
Synthesis, and Application of Nucleoside/Nucleotides” 2019, 24(19), 3433-3448,
doi:10.3390/molecules24193433.
3. Cawrse, B. M.; Robinson, N. M.; Lee, N. C.; Wilson, G. M.; *Seley-Radtke, K L.; Structural
and biological Investigations for a series of N-5 substituted pyrrolo[3,2-d]pyrimidines as
potential anticancer therapeutics. Molecules: Bioactive Nucleosides and Nucleotides 2019,
24, 2656-68; doi:10.3390/molecules24142656.
4. Ku, T.; Lopresti, N.; Shirley, M.; Mori, M.; Marchant, J.; Heng, X.; Botta, M.; Summers, M. F.;
*Seley-Radtke, K. L. Synthesis of Distal and Proximal Fleximer Base Analogues and
Evaluation in the Nucleocapsid Protein of HIV-1. Bioorganic Med Chem; 2019, 27, 2883-92.
5. Yates, M. and *Seley-Radtke, K. L., “The evolution of nucleoside analogue antivirals: a
review for chemists and non-chemists. Part II: complex modifications to the nucleoside
scaffold” Antiviral Res. 2019, 162, 5-21. Highlighted article.
6. Khandazhinskaya, A. L.; Alexandrova, L.A.; Matyugina, E. S.; Solyev, P. N.; Efremenkova,
O. V.; Buckheit, K. W.; Garvey, M.; Buckheit Jr, R. W.; Chernousova, L. N.; Smirnova, T. G.;
Andreevskaya, S. N.; Leonova, O. G.; Popenko, V. I.; Kochetkov, S. N.; *Seley-Radtke, K. L.
“Novel 5’-Norcarbocyclic Pyrimidine Derivatives” as Antibacterial Agents, Molecules, 2018,
23, 3069-87.
7. *Seley-Radtke, K. L. and Yates, M. “The evolution of nucleoside analogue antivirals: a
review for chemists and non-chemists. Part I: early structural modifications to the nucleoside
scaffold.” Antiviral Res. 2018, 154, 66-86. Highlighted article.
8. Temburnikar, K.; *Seley-Radtke, K. L.; “Recent advances in synthetic approaches to C-
nucleosides”, Beilstein J Org Chem 2018, 14, 772-785.
9. *Seley-Radtke, K. L. “Flexibility – not just for Yoga!” Antiviral Chem Chemoth, 2018, 26, 1-
12. Highlighted article.
10. Eyer, L.; Nencka, R.; de Clercq, E.; Seley-Radtke, K.L.; Růžek, D. “Nucleoside analogues as
a rich source of antiviral agents against arthropod-borne flaviviruses”, Antiviral Chem
Chemother 2018, 26, 1-28.
11. Cawrse, B.M.; Lapidus, R.S.; Cooper, B.; Choi, E. Y.; *Seley-Radtke, K.L.; “Antiproliferative
Effects of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity Via N5
Substitution.” ChemMedChem 2018, 13, 178-185.
12. Alzahrani, K. J.; Khandazhinskaya, A. L.; Matyugina, E. S.; Kochetkov, S. N.; *Seley-
Radtke, K. L.; *de Koning, H. P; “Evaluation of the antiprotozoan properties of 5’-
norcarbocyclic pyrimidine nucleosides” Bioorganic Med Chem Lett 2017, 27, 3081-3086.
13. Yates, M.; Raje, M.; Chatterjee, Soloveva, V.; Bavari, S.; *Seley-Radtke, K. L. “Antiviral
Activity for a series of Flex-nucleoside prodrugs against the filoviruses” Bioorg Med Chem
Lett 2017, 27, 2800-2802.
14. Paramonova, M. P.; Khandazhinskaya, A. L.; *Seley-Radtke, K. L.; Novikov, M. S.
"Synthesis of novel 2-[3-[5-(4-bromophenoxy)pentyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-
yl]-N-arylacetamides as potential antivirals" Mendeleev Communications 2017, 27, 85-87.
15. Geisman, A. N.; Valuev-Elliston, V. T.; Ozerov, A. A.; Khandazhinskaya, A. L.; Chizhov, A.
O.; Kochetkov, S. N.; Pannecouque, C.; Naesens, L.; *Seley-Radtke, K. L.; Novikov, M. S.

"1,6-Bis[(benzyloxy)methyl]uracil derivatives – novel antivirals with activity against HIV-1
and influenza H1N1" Bioorg Med Chem, 2016, 24, 2476-2485.
16. Peters, H. L.; Ku, T. C.; *Seley-Radtke, K. L. "Flexibility as a Strategy in Nucleoside Antiviral
Drug Design" Curr Med Chem 2015, 22, 3910-3921.
17. Matugina, E. S.; Novikov, M. S.; Babkov, D. A.; Ozerov, A. A.; Chernousova, L. N.;
Andreevskaya, S.; Smirnova, T. G.; Karpenko, I.; Chizhov, A. O.; Muthu, P.; Lutz, S.;
Kochetkov, N. S.; *Seley-Radtke, K. L.; Khandazhinskaya, A. L.; "5-Arylaminouracil
derivatives: new inhibitors of M. tuberculosis" Chemical Biology & Drug Design 2015, 86,
1387-1396. *corresponding author
18. Chen, Z.; Ku, T. C.; *Seley-Radtke, K. L. "Thiophene-expanded guanosine analogues of
Gemcitabine" Bioorg Med Chem Lett. 2015, 25, 4274-4276.
19. Babkov, D. A.; Khandazhinskaya, A.; Chizhov, A. O.; Andrei, G.; Snoeck, R.; *Seley-Radtke,
K. L., Novikov, M. S. "Toward the Discovery of Dual HCMV-VZV Inhibitors: Synthesis,
Structure-Activity Relationship Analysis, and Cytotoxicity Studies of Long Chained 2-Uracil-
3-yl-N-(4-phenoxyphenyl)acetamides". Bioorg Chem Med Chem 2015, 23, 7035-7044.
*corresponding author.
20. Fateev, I. V.; Kharitonova, M. I.; Esipov, R. S.; Antonov, K. V.; Konstantinova, I. D.;
Stepanenko, V. N.; Seela, F.; Temburnikar, K. W.; *Seley-Radtke, K. L.; Stepchenko, V. A.;
Sokolov, Y. A.; Miroshnikov, A. I.; Mikhailopulo, I. A.; "Recognition of the Challenging
Heterocyclic Bases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant"
Chem. Eur. J. 2015, 21, 13146-13156.
21. Chen, Z.; Jochmans, D.; Ku, T.; Paeshuys, J.; Neyts, J.; *Seley-Radtke, K. L. "Bicyclic and
tricyclic nucleobase analogues of Sofosbuvir – new scaffolds for Hepatitis C therapies", ACS
Infect. Dis., 2015, 1, 357–366.
22. Temburnikar, K.; Ross, C.; Wilson, G.; Balzarini, J.; Cawrse, B.; *Seley-Radtke, K. L.
"Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines" Bioorg Med Chem
2015, 23, 4354-4363.
23. Peters, H. L.; Jochman, D.; Posthuma, C. C.; de Wilde, A.; Snijder, E.; Neyts, J.; *Seley-
Radtke, K. L.; "Design, Synthesis and Anti-coronavirus Activity of a Series of Acyclic
Fleximer Analogues" Bioorg Med Chem Lett 2015, 25, 2923-2926.
24. Babkov, D. A,; Chizhov, A. O,; Khandazhinskaya, A. L.; Corona, A.; Esposito, F.;
Tramontano, E.; *Seley-Radtke, K. L.; Novikov, M. S. "An efficient route to novel uracil
based drug-like heterocycles" Synthesis 2015, 47,1413-1422. *corresponding author.
25. Ross, C. R.; Temburnikar, K. W.; Wilson, G. M.; *Seley-Radtke; K. L.; "Mitotic Arrest of
Breast Cancer MDA-MB-231 Cells by Halogenated Thieno[3,2-d]pyrimidines" Bioorganic
Med Chem Lett. 2015, 25, 1715-1717.
26. Babkov, D. A.; Valuev-Elliston, V. T.; Paramonova, M. P.; Ozerov, A. A.; Ivanov, A. V.;
Chizhov, A. O.; Khandazhinskaya, A. L.; Kochetkov, S. N.; Balzarini, J.; Dalemans, D.;
Pannecouque, C.; *Seley-Radtke, K. L.; Novikov, M. S. "Scaffold hopping: exploration of
acetanilide-containing uracil analogues as potential NNRTIs" Bioorg Med Chem 2015, 23,
1069-1081. *corresponding author

Invited (Peer-reviewed) Book Chapters

1. Ku, T. C.; *Seley-Radtke, K. L. “Design and Synthesis of Fleximers. A Novel Class of
Structurally Diverse Nucleosides”, in “New Trends in Enzymatic and Chemical synthesis of
Nucleic Acid Derivatives”, Jesús Fernández-Lucas and María-José Camarasa Rius eds.
Wiley-VCH, Weinheim, Germany, 2019, Chapter 8, 195-255.
2. Zimmermann, S. C.; *Seley-Radtke, K. L. "Flexible nucleobase analogues. New tools for
nucleic acid discoveries", in RNA Technologies: DNA and RNA Chemical Biology in Science
and Medicine, V. A. Erdmann, W. T. Markiewicz and J. Barciszewski eds. Springer, NY, NY
2014, pp 149-165.
3. *Seley, K. L.; Mosley, S. L. "Purine Analogues and Their Role in Methylation and Cancer
Chemotherapy" in DNA Methylation and Cancer Therapy, Moshe Szyf, Ed. Landes
Bioscience, Georgetown, TX, 2004, Chapter 13, pp 178-186.
4. *Seley, K. L. "Tricyclic Nucleosides Revisited" in Recent Advances in Nucleosides:
Chemistry and Chemotherapy, pg. 299-326, C.K. Chu, Ed. Elsevier Science, 2002.
5. Schneller, S. W.; Seley, K. L.; Hegde, V. R.; Rajappan, V. P. "5′-Norcarbanucleosides in L-
Like Configurations" in Recent Advances in Nucleosides: Chemistry and Chemotherapy, pg.
291-297; C.K. Chu, Ed. Elsevier Science, 2002.

Professional Experience

Higher Education

2017               Distinguished Visiting Professor, Université d’Orléans, Orléans, France

2017-2018       University System of Maryland Regents’ Professor for Excellent in Research

2015-2018       UMBC Presidential Research Professor

2015-2016       Chair, University Faculty Promotion and Tenure Review Committee (UFRC)

2011-present   Professor, Chemistry & Biochemistry, UMBC, & Joint UMB Biochemistry program

2010-present   Auburn University COSAM Advisory Council member

2009-present   UMBC Honors College Advisory Board member

2008-2010       UMBC Honors Program Faculty Fellow

2007-present   NIH Chemistry Biology Interface Graduate Program, Director and mentor

2007-2008       UMBC President’s Commission on Women, Faculty representative

2005-present   Program in Oncology, Greenebaum Cancer Center, Faculty Member

2005-present   Auburn University Society of Women in Sciences & Mathematics Board Member

2004-2006       UMBC Graduate Summer Bridge Program, Founder & Inaugural Director

2003-present   NIH/UMBC Meyerhoff Minority Graduate & Undergraduate Faculty mentor

2003-present   NSF UMBC MARC U*STAR program, Faculty mentor

2003-2004       NSF UMBC EMBARC (REU) Program, Program Director

2003-2011       Associate Professor, Chemistry & Biochemistry, UMBC

1998-2003       Assistant Professor, Chemistry & Biochemistry, Georgia Institute of Technology

1997-98          Visiting Assistant Professor, Auburn University

1996-98          Postdoctoral Research Fellow, Auburn University

Other than Higher Education:

2020-2022 President-elect, International Society for Antiviral Research (ISAR)

2020-2021 Co-Chair, Gordon Research Conference on Nucleosides, Nucleotides & Oligonucleotides

2020 NIH Review panel – Antimicrobial Therapeutics and Resistance – Co-Chair, March 19-20, July (TBD)

2020 NIH Review panel: ZRG1 BCMB-A; NIH Transformative Research Awards, April 7

2018-2019 Co-Vice Chair, Gordon Research Conference on Nucleosides, Nucleotides & Oligonucleotides, June 23-29, 2019

2019-2023 Secretary, International Society of Nucleosides, Nucleotides & Nucleic Acids (IS3NA)

2019 NIH Review panel – Antimicrobial Therapeutics and Resistance – Co-Chair, March 25-26, June 3-4 and Nov 7-8, July 31 (Chair)

2019 Session Chair, Advances in Noncanonical Nucleic Acids, Rogaška Slatina, Slovenia, Oct 17-19.

2019 Session Chair, Gordon Research Conference on Nucleosides, Nucleotides & Oligonucleotides, June 23-29

2019 NIH ZRG1 IMM-R(50) U.S.-Brazil Collaborative Biomedical Research Program, ad hoc reviewer, July 16

2019 Session Chair, 32nd International Conference on Antiviral Research, Baltimore, May 12-15th, 2019.

2019 NIH Review panel – Antimicrobial Therapeutics and Resistance – Co-Chair, March 25-26, June 3-4, and Nov 7-8; July 31 (Chair)

2018 Session Chair, Advances in Noncanonical Nucleic Acids, Portorož, Slovenia, Oct 25-27.

2018 Session Chair and Co-organizer, XXIII International Roundtable on Nucleosides, Nucleotides & Nucleic Acids, San Diego, August 26-30

2018 Session Chair, 31st International Conference for Antiviral Research (ICAR), Porto, Portugal, June 11-15

2018 NIH Special Emphasis Panel – Antimicrobial Therapeutics and Resistance – ZRG1 IDM-Y (82) and 2018/05 ZRG1 IDM-T (07)S, March 28-29, June 28-29, Nov 15-16

2018 Session Chair, 7th European Workshop in Drug Synthesis, Siena, Italy, May 24

2018-present Section Editor, Molecules – Chemical Biology

2018 Special Collections Editor, “Advances in Antiviral Nucleoside Analogues and Their Prodrugs“, Antiviral Chemistry & Chemotherapy

2017 NIH Special Emphasis Panel – Antimicrobial Therapeutics and Resistance ZRG1 IDM-Y (82), Nov 2-3

2017 NIH/NCI ZCA1 SRBK NCI Clinical and Translational R21 & Omnibus R03 review panel, Vice Chair, June 13-14

2017-2018 Immediate Past President, International Society for Nucleosides, Nucleotides & Nucleic Acids (IS3NA)

2017-2018 Chair, Nominations Committee, IS3NA

2017-present Chair, The Chu Family Foundation awards, International Society of Antiviral Research (ISAR)

2017 Session Chair, Gordon Research Conference on Nucleosides, Nucleotides & Oligonucleotides, Salve Regina University, Newport, RI, June 25-30

2017 Session Chair, 30th International Conference on Antiviral Research, Atlanta, GA, May 21-25

2016-present Associate Editor, Antiviral Chemistry & Chemotherapy

2016 NIH/NIGMS ZGM1 TRN-Y, Maximizing Investigators Research Awards (MIRA) review panel, Nov 10-11

2016 NIH ZAI1-JRR-M-J3 Rapid Assessment of Zika Virus (ZIKV) Complications review panel, ad hoc member and vice chair, Oct 20

2016 NIH AIDS Discovery & Development of Therapeutics (ADDT) study section, ad hoc member, July 26

2016 NIH F04A-Y(20)L T31/T32 Fellowship study section, ad hoc member, July 13

2016 Session Chair, XXII International Roundtable on Nucleosides, Nucleotides & Nucleic Acids, Paris, France, July 18-21

2016 Session Chair, 6th European Workshop in Drug Synthesis, Siena, Italy, May 17

2016 Session Chair, 5th Antiviral Drugs Research & Development, San Diego, June 1

2016 Conference Committee, 29th International Conference on Antiviral Research, San Diego, CA

2016 Session Chair, 29th International Conference on Antiviral Research, San Diego, CA, April 19

2015-2016 President, International Society on Nucleosides, Nucleotides & Nucleic Acids (IS3NA)

2016-2018 Board of Directors, International Society for Antiviral Research (ISAR)

2016-present  Chair, The Chu Family Women in Science Awards Committee, ISAR

2016-present Chair, The Chu Family Early Career Awards Committee, IS3NA

2015 NIH/NIGMS ZGM1 TRN-Y, Maximizing Investigators Research Awards (MIRA) review panel

2015-present Women in Science Scholarship Committee, ISAR

2015-present UMBC Meyerhoff Program Advisory Board

2015 NIH/NCI ZCA1 SRB-2 Drug Development & Targeting Special Emphasis Panel, Acting Chair

2015 Session Chair, 10th European Workshop in Drug Design, Siena, Italy, May 18-22

2105 Session Chair, 28th International Conference on Antiviral Research, Rome, Italy, May 11-15

2014 Session Chair, 21st International Roundtable on Nucleosides, Nucleotides & Nucleic Acids, August 24-28, Poznan, Poland

2014-present Program Committee, ISAR

2014 Broadening Experiences in Scientific Training, Advisory Board member, University of Notre Dame Ph.D. program

2014 Session Chair, National ACS Medicinal Chemistry Symposium, Charleston, SC, May 18, 2014

2014 Session Chair, 27th International Conference on Antiviral Research (ICAR), Raleigh, May 12-15

2014 NIH ZRG1 AARR-J PAR Panel: Sustained Release of Antivirals for Treatment or Prevention of HIV, Acting Chair

2013-present Women in Chemistry Committee, ISAR

2013-2016 Board of Directors, ISAR

2013 NIH/NCI ZCA1 SRLB-2 Exploratory/Developmental Research study section

2013-2014 Vice President, IS3NA

2013-2014 Co-organizer, National ACS Medicinal Chemistry Symposium, Charleston, SC, May 18-21, 2014

2013-2014 Session Chair, National ACS Medicinal Chemistry Symposium, Charleston, SC, May 18-21, 2014

2013-2017 Award Nomination & Selection Committee, ACS Medicinal Chemistry Division

2013 Session Chair, 26th ICAR, San Francisco, May 10-16

2012-2017 ISAR Poster Award Committee Chair

2012-present Editorial Board, Clinical Medicine Insights, Therapeutics

2012 Med Chem Session Chair, 244th National ACS meeting, Philadelphia, PA

2012 Session Chair, 4th European Workshop in Drug Synthesis, May 28, Siena, Italy

2012 Med Chem Session Chair, 243rd National ACS meeting, San Diego, CA

2012 NIH ZRG1 Member Conflict study section (ad hoc)

2011-2013 Editorial Board, Research and Reports in Medicinal Chemistry

2011 Med Chem Session Chair, 242nd National ACS meeting, Denver, CO.

2011 Session Chair, 8th European Workshop in Drug Design, May 22-28, Siena, Italy

2011-present Associate Editor, Current Protocols in Chemical Biology

2010-2014 NIH AIDS Discovery & Development of Therapeutics (ADDT) study section, member (Vice Chair – 2013-2014)

2010-2012 ACS Div. of Med. Chem. Long Range Planning Committee

2007-2012      Secretary, IS3NA

2010 Session Chair, 19th International Roundtable on Nucleosides, Nucleotides & Nucleic Acids, August 29-Sept 3, 2010, Lyon, France

2009 NSF Chemical Synthesis study section

2008-present NAS Jefferson Science Fellowship Selection Committee

2008-2012 Scientific Advisory Board, Deszyme Inc.

2008 Session Chair, 12th Indian Society of Chemists & Biologists Int. Conf. on “The Interface of Chemistry-Biology in Biomedical Research“, Pilani, India

2007-2016 U.S. Embassy, Moscow Russia, Senior Science Advisor

2007 Women in International Security (WIIS) workshop “Science, Technology and U.S. National Security: Engaging the Next Generation” invited panel member and discussion leader, Washington, DC

2006-present NAS Jefferson Science Fellow, U.S. Department of State

2005-2010 NIH/NIGMS Biomedical Research Training-A and-B study sections member

2005-present IS3NA, Membership (Chair), Publications & website committees

2005-present ISAR, Career Development Committee, Poster Awards Committee

2004-2008 Merck/AAAS Undergraduate Science Research Program (USRP) Selection Committee Member

2004 NIH Tropical Medicine & Parasitology Study Section member (ad hoc)

2004 Session Chair, International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Minneapolis, MN

2003 NIH Tropical Medicine & Parasitology Study Section member (ad hoc)

2003 Session Chair, Gordon Research Conference, Purines, Pyrimidines & Related Substances, Newport, RI

2002               NIH Bioorganic & Natural Products Study Section member (ad hoc)

2002 NIH BNZP Bioengineering Study Section member (ad hoc)

Honors, Awards, and Distinctions:

2020 International Society for Antiviral Research (ISAR) Antonín Holý Memorial Award

2017 USM Regents’ Faculty Award for Excellence in Research

2016 Maryland Chemist of the Year, American Chemical Society

2015-2018 UMBC Presidential Research Professor

2015 Outstanding Chemistry Alumni Award, University of South Florida

2011 Outstanding Faculty Member of the Year, UMBC Honors College students

2008-2010 Inaugural Faculty Fellow, UMBC Honors College Program

2006 NAS Jefferson Science Fellow, U.S. Department of State

2006 Distinguished Faculty Award, The National Society of Collegiate Scholars

2003 ACS PROGRESS Lectureship in Chemical Sciences Award

2002 “Class Of 1940 W. Howard Ector Outstanding Teacher” Georgia Institute of Technology ($10,000 prize)

1998 Outstanding Faculty Award, Cardinal Key Honor Society, Auburn University

1997 Sigma Xi Outstanding Dissertation, Auburn University

1997 Carolyn Taylor Carr Award, Auburn University

1992 American Association of University Women Scholarship, U. of South Florida

1992 Hugh Culverhouse Outstanding Graduate Student Award, U. of South Florida

Courses Taught

  • CHEM 299: Training in Experimental Chemistry (Cooperative Education)
  • CHEM 351: Organic Chemistry I
  • CHEM 351L: Organic Chemistry Laboratory I
  • CHEM 352: Organic Chemistry II
  • CHEM 352L: Organic Chemistry Laboratory II
  • CHEM 399: Tutorial Projects in Chemistry
  • CHEM 450: Chemistry of Heterocyclic Compounds
  • CHEM 453: Organic Chemistry of Nucleic Acids
  • CHEM 455: Introduction to Biomedicinal Chemistry
  • CHEM 490: Special Topics in Chemistry – Organic Synthetic Methology
  • CHEM 499: Undergraduate Research
  • CHEM 600: Advanced Laboratory Projects
  • CHEM 602: Introduction to Laboratory Research
  • CHEM 650: Chemistry of Heterocyclic Compounds
  • CHEM 653: Organic Chemistry of Nucleic Acids
  • CHEM 654: Organic Synthetic Methodology
  • CHEM 655: Introduction to Biomedicinal Chemistry
  • CHEM 713: Biochemistry/Chemistry Seminar
  • CHEM 715: Issues at the Chemistry/Biology Interface
  • CHEM 898: Pre-Candidacy Doctoral Research
  • CHEM 899: Doctoral Dissertation Research