Jan Marchant

Contact Description Office: MEYR 184 Phone: 410-455-6347 Email: jmarchant@umbc.edu

Professional Interests

Our research focuses on the development and application of novel NMR and computational methods for studying the structure, dynamics, and interactions of large RNAs and protein-RNA complexes of biological and pathogenic importance. We primarily use these tools to study the mechanisms by which HIV exports its genome from the nucleus, a vital step in its life cycle. In recent years we have determined structures of RNA elements of up to 75 kDa which are recognized by viral proteins prior to export. We now wish to use these structures, and the techniques we have developed, to better understand how these elements interact with viral proteins during selection of RNA for nuclear export and genome packaging.

Selected Publications

2019   J Marchant, MF Summers, BA Johnson, “Assigning NMR spectra of RNA, peptides and small organic molecules using molecular network visualization software”, J. Biomol. NMR, 73 (10), 525-529

2019   M Strickland, J Catazaro, R Rajasekaran, M-P Strub, C O’Hern, GA Bermejo, MF Summers, J Marchant, N Tjandra, “Long-range RNA structural information via a paramagnetically tagged reporter protein”, J. Am. Chem. Soc., 141 (4), pp 1430–1434

2018   J Marchant, A Bax, M Summers, “Variable Flip Angle Heteronuclear NMR for Measurement of Residual Dipolar Couplings in Large RNAs”, J. Am. Chem. Soc., 140 (22), pp 6978–6983

2016   M Norris, B Fetler, J Marchant, BA Johnson, “NMRFx Processor: a cross-platform NMR data processing program”, Journal of Biomolecular NMR 65 (3-4), 205-216

2016   PY Mercredi, N Bucca, B Loeliger, CR Gaines, M Mehta, P Bhargava, PR Tedbury, L Charlier, N Floquet, D Muriaux, C Favard, CR Sanders, EO Freed, J Marchant, MF Summers, “Structural and molecular determinants of membrane binding by the HIV-1 matrix protein”, Journal of Molecular Biology 428 (8), 1637-1655

Full list: https://scholar.google.com/citations?user=JPHosNIAAAAJ