Paul Smith

Paul
Contact Information
Office: MEYR 405B
Phone: 410-455-2519

Associate Professor

Research Interests

Design and synthesis of inhibitors of replication by Hepatitis C, including analogs of the natural product UK-1 that inhibit the viral helicase enzyme.

Selected Publications

  1. Talley, D.C.; Delang, L.; Neyts, J.; Leyssen, P.; Smith, P.J. “Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors” Bioorg. Med. Chem. Lett. 2016, 26, 1196-1199.
  2. Ward, D.N.; Talley, D.C.; Tavag, M.; Menji, S.; Schaughency, P.; Baier, A.; Smith, P.J. “UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication” Bioorg. Med. Chem. Lett. 2014, 24, 609-612.
  3. P.J. Smith and J.F. Liebman, “Distorted Aromatics” in Strained Hydrocarbons: Beyond the van’t Hoff and LeBel Hypothesis, ed. H. Dodziuk, pp.147-153, Wiley-VCH, 2009.
  4. Lenoir, D.; Smith, P.J.; Liebman, J.F. “Nonplanar Alkenes” in Strained Hydrocarbons: Beyond the van’t Hoff and LeBel Hypothesis, ed. H. Dodziuk, pp.103-112, Wiley-VCH, 2009.
  5. Judge, S. I. V.;  Smith, P. J.;  Stewart, P. E.; Bever, Jr., C. T. “Potassium Channel Blockers and Openers as CNS Neurologic Therapeutic Agents” Recent Pat. CNS Drug Discov. 2007, 2, 200-228.