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Michael Summers

Contact Information
Office: CHEM 182A
Phone: 410-455-2527

Professor

Ph.D. Emory University 1984; B.S. University of West Florida 1980

Professional Interests

Our research efforts are aimed at understanding how retroviruses assemble and how they specifically recognized and package their genetic material.  Over the past decade or so, we and others have determined the 3D structures of several isolated protein components that make up HIV-1 (the retrovirus that causes AIDS).  We now wish to understand how these components interact with each other and with cellular constituents.  We are also interested in understanding how these intermolecular interactions change when the initially-formed retrovirus matures and become infectious.  In the long term, we would like to use the basic structural and functional information obtained to design new therapeutic approaches for the treatment of AIDS and other human diseases caused by retroviruses.

Selected Publications

  1. NMR-based structural studies indicate that the cellular phosphatidylinosititde, PIP2 (yellow) binds to a conserved cleft on the HIV-1 matrix protein, triggering myristate (green) exposure and membrane binding.

    Zhou, J., Bean, Rebecca L., Vogt, V. M., Summers, M. F. “Solution Structure of the Rous Sarcoma Virus Nucleocapsid Protein:mY RNA Packaging Signal Complex”, J. Mol. Biol. 365, 453-467 (2006).

  2. Saad, J. S., Loeliger, E., Luncsford, P., Liriano, M., Tai, J., Kim, A., Miller, J., Joshi, A., Freed, E. O., Summers, M. F. “Point mutations in the HIV-1 matrix protein turn off the myristyl switch”, J. Mol. Biol. 366, 574-585 (2007).
  3. Saad, J. S., Miller, J., Tai, J., Kim, A., Ghanam, R. H., Summers, M. F. “Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly,” Proc. Natl. Acad. Sci. U.S.A., 103, 11364-11369 (2006).
  4. Summers, M. F., Hrabowski, F. A. III, “Preparing minority scientists and engineers,” Science 311, 1870-1871 (2006).
  5. D’Souza, V., Summers, M. F. “How retroviruses recognize and package their RNA genomes,” Nature Reviews Microbiology 3, 643-655 (2005).
  6. D’Souza, V. D., Summers, M. F., ‘Structural Basis for Packaging the Dimeric Genome of Moloney Murine Leukemia Virus,’ Nature 431, 586-590 (2004).

Honors and Awards

Maryland Chemist of the Year
American Chemical Society – Maryland Section
2004
AAAS Mentor of the Year Award
American Association for the Advancement of Science
2003
Emily M. Gray Mentor Award
Biophysical Society
2003
William A. Hinton Mentor Award
American Society of Microbiology
2002
White House Presidential Award for Science, Engineering and Math Mentoring
Executive Office of the President, Office of Science and Technology Policy
2000
Presidential Research Professor
UMBC
1999-2002
Meyerhoff Mentor Award
Meyerhoff Scholarship Program, UMBC
1999
Excellence in Research Award
University System of Maryland Regents
1998
Award for Achievements in Magnetic Resonance
Eastern Analytical Symposia
1998
Young Investigator Award
Protein Society
1996
Maryland Distinguished Young Scientist Award
1994
Maryland Distinguished Young Scientist Award
1996
Distinguished Alumnus Award
University of West Florida
1994
Merit Award
National Institutes of Health
1997-2006
Merit Award
National Institutes of Health
2006-2015
Don Creighton Memorial Faculty Award
Graduate Student Association, UMBC
2006

Funding

NMR Studies of Retroviral Nucleic Acid Binding Proteins
NIH/NIGMS
2006-2011
NMR Studies of HIV-1 Proteins
NIH/NIAID
2006-2016 (Merit Award)
Howard Hughes Medical Institute
1994 – Present

Courses Taught

  • CHEM 399: Tutorial Projects in Chemistry
  • CHEM 499: Undergraduate Research