Dr. Xinxin Ding

University of Arizona

Friday, May 10, 2024
12:00 Noon
Room 120 – Meyerhoff Chemistry Building
Host: Dr. Kamal Seneviratne

“Metabolic Mechanisms of Chemical Toxicity in the Lung”

Many drugs or other xenobiotic compounds cause toxicity in a tissue-selective manner. For compounds that require metabolic activation to cause toxicity, this tissue selectivity may coincide with the tissue profile of expression of relevant bioactivation enzymes. Internal exposure or bioavailability of the toxic compound in each organ, which may be related to the routes of exposure or transport, can also be an important factor. However, the metabolic mechanisms become more complicated when intermediate or reactive metabolites are stable enough to be distributed to secondary sites to cause toxicity. Furthermore, tissue-specific defensive or repair mechanisms, or their disruption, may also affect the toxicity outcome. This talk will discuss recent progress in our efforts to dissect these differing mechanisms using the lung as an example.