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William LaCourse

Contact Information
Office: MEYR 243A
Phone: 410-455-2105
LaCourse CV
Lab Website

Professor

Post-Doctoral Iowa State University 1988; Ph.D. Northeastern University 1987; B.S. Charter Oak College 1982

Professional Interests

Dr. LaCourse’s research interests include basic and applied research on hydrodynamic electroanalytical techniques in liquid chromatography and capillary electrophoresis, adsorption phenomena at noble metal electrodes, and advanced sample preparation techniques (e.g., microdialysis and pressurized-fluid extraction). A major thrust of his efforts is to further understand and expand the limits of pulsed electrochemical detection (PED) techniques for the determination of polar aliphatic compounds. Dr. LaCourse applies PED to (bio)analytical problems of critical significance in the areas of pharmaceutical, toxicological, forensic, environmental, pharmaceutical, and life science arenas.
Pulsed Electrochemical Detection

Selected Publications

  1. Lu, Hua; Salimian, Sasan; Gamelin, Emily; Wang, Guoying; Fedorowski, Jennifer; LaCourse, William; Greenberg, Jean, Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis, The Plant Journal, 2008, submitted for publication.
  2. S. Ge, H. Lam, S.J. Modi, W.R. LaCourse, G. Rao, and L. Tolosa, Comparing the Performance of the Optical Glucose Assay Based on Glucose Binding Protein with HPAEC-PED: Efforts to Design a Low-Cost-Point-of-Care Glucose Sensor. J. of Diabetes Science and Tech., 2007, 1(6), 864-872.
  3. An improved method to detect ethyl glucuronide in urine using reversed-phase liquid chromatography and pulsed electrochemical detection, R. Kaushik, and W.R. LaCourse, Anal. Chim. Acta 2007, 576(2), 239-245.
  4. Determination of ethyl glucuronide in urine using reversed-phase HPLC and pulsed electrochemical detection (Part II), Kaushik, R.; LaCourse, W. R.; Levine, B. Anal. Chim. Acta2006,  556(2),  267-274. 
  5. A brief review: HPLC methods to directly detect drug glucuronides in biological matrices (Part I).     Kaushik, R.; Levine, B.; LaCourse, W. R. Anal. Chim. Acta2006,  556(2),  255-266.
  6. Application of Photoassisted Electrochemical Detection to Explosive-Containing Environmental Samples.      Marple, R. L.; LaCourse, W.R. Anal. Chem.2005,  77(20),  6709-6714. 
  7. Microelectrode applications of pulsed electrochemical detection. LaCourse, W. R.; Modi, S. J.  Electroanalysis2005,  17(13),  1141-1152.
  8. A platform for on-site environmental analysis of explosives using high performance liquid chromatography with UV absorbance and photo-assisted electrochemical detection. Marple, R. L.; LaCourse, W. R. Talanta2005,  66(3),  581-590.

 

Honors and Awards

Board of Directors – Member
Society of Electroanalytical Chemists
2006
Assistant Editor
Analytica Chima Acta
2006
Member
Sigma Xi Scientific Research Society
2006
Distinguished Alumni Award
Northeastern University, Boston, MA
2001
Young North American Analytical Faculty
Analytica Chimica Acta
1995

Meetings/Events

International ion Chromatoraphy Symposium
The IIC symposia series is THE forum for scientists interested in the separation of inorganic and organic ions. This meeting offers a focused overview of the latest developments in ion analysis by ion chromatography and capillary electrophoresis, together with workshops covering the practical implementation of these techniques in a wide range of application areas.

Courses Taught

  • CHEM 100: The Chemical World
  • CHEM 101: Principles of Chemistry I
  • CHEM 102: Principles of Chemistry II
  • CHEM 300: Analytical Chemistry
  • CHEM 461: Advanced Instrumental Methods of Analysis
  • CHEM 398: Lead, Science and Society
  • CHEM 399: Tutorial Projects in Chemistry
  • CHEM 499: Undergraduate Research
  • CHEM 490: Special Topics in Chemistry

 

Research Description

In the Faraday Cage
The LaCourse Group – 2005

Research in the LaCourse group involves the development of tools and methodology for the determination of polar aliphatic compounds (e.g., carbohydrates, amines, and sulfur-containing moieties with weak chromophores) in a variety of matrices. Hence, our research interests include basic and applied research on hydrodynamic electroanalytical techniques, adsorption phenomena at noble metal electrodes,practically all chromatographic techniques including capillary electrophoresis,  and advanced sample preparation techniques (e.g., microdialysis and pressurized-fluid extraction). The LaCourse group is known world wide for its research on Pulsed Electrochemical Detection.