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Drug Design/Synthesis

Development of new agents with potential for beneficial impact on human health is an area of significant interest in the Department. This entails both chemical synthesis and also studies seeking to understand the molecular basis of the intended or known pharmacological action. Specific projects cover a broad spectrum of interests. These include; the construction and study of agents with potent anti-viral, anti-biotic or anti-cancer properties; synthesis of signal cascade disruptors/enhancers; development of artificial blood; study of structure-activity relations and enzyme mechanism and inhibition; as well as understanding general mechanisms of drug action and the molecular basis of cancer chemoprevention.
FACULTY WITH RESEARCH INTERESTS IN DRUG DESIGN/SYNTHESIS

An, Songon
High-content imaging for drug discovery

Fishbein, James
Delineating the mechanistic basis by which cancer chemoprotective compounds manifest their activity with a view toward improving efficacy.

Johnson, Bruce
Computational methods for analysis of metabolomics data for research into drug toxicity and mechanism.

Seley-Radtke, Katherine
Discovery, design and synthesis of enzyme inhibitors for use as medicinal agents with chemotherapeutic emphasis in the areas of anticancer, antiviral, and antiparasitic targets.

Thorpe, Ian
Using molecular simulation and modeling to understand how drugs interact with biomolecules to carry out their functions.